Prodrug

Definition

A prodrug is an inactive compound that is metabolized in the body to produce an active drug. Prodrugs are often used to improve the pharmacokinetic and pharmacodynamic properties of medications.

5 Must Know Facts For Your Next Test

1. Prodrugs can enhance the absorption, distribution, metabolism, and excretion (ADME) profiles of medications.
2. Lisdexamfetamine is a common example of a prodrug used as a CNS stimulant for ADHD treatment.
3. Prodrugs are designed to overcome issues such as poor solubility or stability of the active drug.
4. The conversion of a prodrug to its active form usually occurs via enzymatic processes in the liver.
5. Prodrugs may reduce side effects by targeting specific tissues or cells where activation occurs.

Review Questions

• What is the primary purpose of using a prodrug in medication?
• Can you name a commonly used CNS stimulant that functions as a prodrug?
• How do prodrugs generally improve the pharmacokinetic properties of medications?

Related terms

Enzyme: A protein that catalyzes chemical reactions, including the conversion of prodrugs to active drugs.

Pharmacokinetics:

The study of how drugs move through the body, including absorption, distribution, metabolism, and excretion.

Active Metabolite: The biologically active form of a drug after it has been metabolized in the body.