Prasugrel is an antiplatelet medication that inhibits platelet activation and aggregation by irreversibly binding to the P2Y12 receptor on platelets. It is commonly used to prevent blood clots in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI).
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Prasugrel has a more rapid onset of action compared to clopidogrel.
It is contraindicated in patients with a history of stroke or transient ischemic attack (TIA).
The typical maintenance dose for prasugrel is 10 mg once daily.
Patients weighing less than 60 kg may require a reduced dose of 5 mg daily.
Prasugrel can significantly increase the risk of bleeding, especially in older adults.
Review Questions
What is the mechanism of action for prasugrel?
Why is prasugrel contraindicated in patients with a history of stroke?
What is the recommended dosage adjustment for prasugrel in patients weighing less than 60 kg?
Related terms
Clopidogrel: An antiplatelet drug that also inhibits the P2Y12 receptor but has a slower onset of action compared to prasugrel.
Ticagrelor: Another P2Y12 inhibitor used as an antiplatelet agent, known for its reversible binding to platelets.
Percutaneous Coronary Intervention (PCI): A non-surgical procedure used to treat narrowing of the coronary arteries of the heart found in coronary artery disease.