Phosphodiesterase-5 (PDE5) inhibitors are a class of medications that work by blocking the action of the enzyme PDE5, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the body. This mechanism of action allows for the increased availability of cGMP, leading to vasodilation and improved blood flow, particularly in the penis, which is the primary therapeutic effect of PDE5 inhibitors.
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