PD-1 Inhibitors
from class: Pharmacology for Nurses Definition PD-1 inhibitors are a class of drugs that block the programmed cell death protein 1 (PD-1) pathway, enhancing the immune system's ability to attack cancer cells. They are a type of immune checkpoint inhibitor used in cancer immunotherapy.
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Predict what's on your test 5 Must Know Facts For Your Next Test PD-1 inhibitors help prevent cancer cells from evading the immune system. Common PD-1 inhibitors include pembrolizumab (Keytruda) and nivolumab (Opdivo). They are primarily used to treat various cancers like melanoma, non-small cell lung cancer, and renal cell carcinoma. PD-1 inhibitors can cause side effects such as fatigue, rash, and immune-related adverse effects like colitis or pneumonitis. These drugs work by binding to PD-1 receptors on T-cells, blocking their interaction with PD-L1/PD-L2 on tumor cells. Review Questions What is the primary mechanism of action for PD-1 inhibitors? Name two common PD-1 inhibitors used in clinical practice. List at least two types of cancers that can be treated with PD-1 inhibitors.
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