Oxazolidinones

Definition

Oxazolidinones are a class of synthetic antibiotics effective against Gram-positive bacteria. They inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit.

5 Must Know Facts For Your Next Test

1. Linezolid is the most commonly used oxazolidinone in clinical practice.
2. Oxazolidinones are particularly effective against multidrug-resistant organisms like MRSA and VRE.
3. They can cause side effects such as thrombocytopenia, neuropathy, and serotonin syndrome when combined with serotonergic drugs.
4. Oxazolidinones have a unique mechanism of action compared to other antibiotics, making cross-resistance less likely.
5. These drugs are usually administered orally or intravenously.

Review Questions

• What is the primary mechanism of action for oxazolidinones?
• Name a common clinical use for oxazolidinones.
• What are potential side effects associated with oxazolidinone therapy?

Related terms

Linezolid: A widely-used oxazolidinone antibiotic effective against Gram-positive bacteria.

MRSA (Methicillin-Resistant Staphylococcus Aureus): A type of staph bacteria that is resistant to many antibiotics, including methicillin.

VRE (Vancomycin-Resistant Enterococci): Enterococci bacteria that have developed resistance to vancomycin, often treated with oxazolidinones.