Pharmacology for Nurses

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Ondansetron

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Pharmacology for Nurses

Definition

Ondansetron is an antiemetic medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. It works by blocking serotonin receptors in the brain and gastrointestinal tract.

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5 Must Know Facts For Your Next Test

  1. Ondansetron is commonly administered orally, intravenously, or via dissolvable tablets.
  2. The main mechanism of action involves the antagonism of the serotonin 5-HT3 receptors.
  3. It is often prescribed preemptively before chemotherapy or postoperatively to manage nausea and vomiting.
  4. Common side effects include headache, constipation, and dizziness.
  5. Ondansetron does not significantly interact with other drugs metabolized by cytochrome P450 enzymes.

Review Questions

  • What is the primary mechanism of action of ondansetron?
  • In what forms can ondansetron be administered?
  • Name two common side effects of ondansetron.

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