Omeprazole

Definition

Omeprazole is a proton-pump inhibitor (PPI) that reduces stomach acid production. It is commonly used to treat conditions like GERD, ulcers, and Zollinger-Ellison syndrome.

5 Must Know Facts For Your Next Test

1. Omeprazole works by irreversibly inhibiting the H+/K+ ATPase enzyme in the stomach lining.
2. It is usually administered orally but can also be given intravenously in certain cases.
3. Common side effects include headache, nausea, diarrhea, and abdominal pain.
4. Long-term use of omeprazole can lead to vitamin B12 deficiency and hypomagnesemia.
5. Omeprazole should be taken before meals for optimal effectiveness.

Review Questions

• What enzyme does omeprazole inhibit to reduce stomach acid production?
• What are common side effects associated with omeprazole?
• Why might long-term use of omeprazole lead to nutritional deficiencies?

Related terms

Histamine Blocker: A class of drugs that reduce stomach acid by blocking histamine receptors on parietal cells.

GERD:

Gastroesophageal reflux disease, a chronic condition where stomach acid frequently flows back into the esophagus.

Zollinger-Ellison Syndrome: A disorder caused by tumors that secrete excessive levels of gastrin, leading to increased stomach acid production.