Norepinephrine dopamine reuptake inhibitors (NDRIs)

Definition

Norepinephrine dopamine reuptake inhibitors (NDRIs) are a class of antidepressants that increase the levels of norepinephrine and dopamine in the brain by inhibiting their reuptake into neurons. They are used to treat major depressive disorder and other conditions.

5 Must Know Facts For Your Next Test

1. NDRIs primarily target the neurotransmitters norepinephrine and dopamine, rather than serotonin.
2. Bupropion is the most commonly prescribed NDRI.
3. NDRIs are often used as an alternative for patients who experience sexual dysfunction with SSRIs or SNRIs.
4. Common side effects include insomnia, dry mouth, and increased heart rate.
5. Unlike many other antidepressants, NDRIs generally do not cause weight gain.

Review Questions

• What neurotransmitters do NDRIs primarily affect?
• Name one common NDRI medication.
• What are some typical side effects associated with NDRIs?

Related terms

Selective Serotonin Reuptake Inhibitors (SSRIs): A class of antidepressants that increase serotonin levels by inhibiting its reuptake.

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Antidepressants that increase both serotonin and norepinephrine levels by inhibiting their reuptake.

Monoamine Oxidase Inhibitors (MAOIs): A class of antidepressants that work by blocking the enzyme monoamine oxidase from breaking down neurotransmitters like serotonin, norepinephrine, and dopamine.