Neoangiogenesis
from class: Pharmacology for Nurses Definition Neoangiogenesis is the process of new blood vessel formation from pre-existing vessels, often seen in tumor growth. It is a critical mechanism by which cancerous tumors obtain nutrients and oxygen to sustain rapid proliferation.
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Predict what's on your test 5 Must Know Facts For Your Next Test Neoangiogenesis is crucial for tumor growth and metastasis as it supplies the necessary nutrients and oxygen. Inhibiting neoangiogenesis is a therapeutic strategy in cancer treatment, aimed at 'starving' the tumor. Vascular Endothelial Growth Factor (VEGF) plays a significant role in promoting neoangiogenesis. Anti-angiogenic drugs, such as Bevacizumab, target pathways involved in neoangiogenesis to inhibit tumor growth. Excessive neoangiogenesis can lead to abnormal vessel structure, contributing to inefficient blood flow within tumors. Review Questions Why is neoangiogenesis important for the survival and growth of tumors? Name one key molecule involved in the process of neoangiogenesis and its role. What is the therapeutic goal of anti-angiogenic drugs in cancer therapy?
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