Lovastatin

Definition

Lovastatin is a statin medication used primarily to lower cholesterol levels and reduce the risk of cardiovascular disease. It works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis in the liver.

5 Must Know Facts For Your Next Test

1. Lovastatin is metabolized in the liver primarily via the CYP3A4 pathway.
2. Common side effects include muscle pain, digestive problems, and increased liver enzymes.
3. It is often taken in the evening because cholesterol synthesis occurs predominantly at night.
4. The drug is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases.
5. Grapefruit juice can increase lovastatin levels in the blood, leading to a higher risk of adverse effects.

Review Questions

• What enzyme does lovastatin inhibit to lower cholesterol?
• Why should lovastatin generally be taken in the evening?
• What are common side effects associated with lovastatin use?

Related terms

Statins:

A class of drugs that lower cholesterol levels by inhibiting HMG-CoA reductase.

HMG-CoA Reductase:

An enzyme involved in the synthesis of cholesterol in the liver.

PCSK9 Inhibitors:

A class of drugs that lower LDL cholesterol by enhancing its clearance from the bloodstream.