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Loratadine

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Pharmacology for Nurses

Definition

Loratadine is a second-generation antihistamine used to relieve symptoms of allergy such as runny nose, sneezing, and itching. It has fewer sedative effects compared to first-generation antihistamines.

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5 Must Know Facts For Your Next Test

  1. Loratadine selectively blocks peripheral H1 histamine receptors, reducing allergic symptoms without causing significant drowsiness.
  2. It is commonly administered orally in the form of tablets or syrup.
  3. Loratadine is often used in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria.
  4. The drug is metabolized by the liver and has a half-life ranging from 8 to 14 hours in adults.
  5. Common side effects include headache, fatigue, and dry mouth.

Review Questions

  • What type of receptor does Loratadine target to alleviate allergy symptoms?
  • Why does Loratadine cause less sedation compared to first-generation antihistamines?
  • What are two common conditions treated with Loratadine?

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