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Lomustine

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Pharmacology for Nurses

Definition

Lomustine is an alkylating agent used in chemotherapy to treat various types of cancer, including brain tumors. It works by interfering with DNA replication and RNA transcription, leading to cell death.

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5 Must Know Facts For Your Next Test

  1. Lomustine is administered orally in capsule form.
  2. It is particularly effective in treating glioblastoma and other brain tumors due to its ability to cross the blood-brain barrier.
  3. Common side effects include bone marrow suppression, nausea, and vomiting.
  4. Due to its delayed bone marrow suppression, blood counts need frequent monitoring during treatment.
  5. Lomustine’s dosing is usually done every 6 weeks to allow recovery from hematologic toxicity.

Review Questions

  • What class of chemotherapeutic agents does Lomustine belong to?
  • Why is Lomustine particularly useful for treating brain tumors?
  • What are common side effects associated with Lomustine?

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