Licorice root

Definition

Licorice root is an herbal supplement derived from the Glycyrrhiza glabra plant, commonly used for its anti-inflammatory and antimicrobial properties. It is often employed in alternative medicine to treat respiratory and digestive issues.

5 Must Know Facts For Your Next Test

1. Licorice root contains glycyrrhizin, which can cause potassium depletion and sodium retention, leading to hypertension.
2. It has potential interactions with corticosteroids, diuretics, and antihypertensive medications due to its effects on electrolyte balance.
3. Licorice root may exacerbate conditions like chronic kidney disease or heart failure because of its mineralocorticoid-like effects.
4. Deglycyrrhizinated licorice (DGL) is a form of the herb that has had most of its glycyrrhizin removed and is considered safer for long-term use.
5. High doses or prolonged use of licorice root can lead to pseudoaldosteronism, characterized by symptoms such as edema, hypertension, and hypokalemia.

Review Questions

• What compound in licorice root can lead to electrolyte imbalances?
• Why should patients with chronic kidney disease avoid high doses of licorice root?
• What is the safer form of licorice root for long-term use?

Related terms

Glycyrrhizin: An active compound in licorice root responsible for its sweet flavor and mineralocorticoid-like effects.

Pseudoaldosteronism: A condition resulting from excessive consumption of substances like glycyrrhizin that mimic aldosterone's effects.

Complementary and Alternative Medicine (CAM): A diverse group of medical practices not typically part of conventional medical care, including herbal supplements like licorice root.