Leukotriene modifiers

Definition

Leukotriene modifiers are a class of drugs that block the effects of leukotrienes, which are inflammatory chemicals the body releases after coming into contact with an allergen or irritant. They are primarily used in the management and treatment of asthma and allergic rhinitis.

5 Must Know Facts For Your Next Test

1. Leukotriene modifiers include leukotriene receptor antagonists (LTRAs) like montelukast and zafirlukast, and leukotriene synthesis inhibitors like zileuton.
2. These drugs help prevent bronchoconstriction, inflammation, and mucus production in the airways.
3. They are often used as an add-on therapy for patients whose asthma is not adequately controlled by inhaled corticosteroids.
4. Common side effects may include headache, dizziness, abdominal pain, and mood changes.
5. Leukotriene modifiers can be taken orally, making them a convenient option for long-term management of asthma.

Review Questions

• What is the primary function of leukotriene modifiers in managing respiratory disorders?
• Name two types of leukotriene modifiers and give an example of each.
• What are some common side effects associated with leukotriene modifiers?

Related terms

Xanthines:

A class of drugs that includes theophylline, used to dilate airways in respiratory conditions like asthma.

Mast Cell Stabilizers:

Drugs that prevent mast cells from releasing histamine and other inflammatory mediators; used in treating allergic reactions.

Inhaled Corticosteroids:

Anti-inflammatory medications commonly used to control chronic asthma symptoms when inhaled directly into the lungs.