Leqvio

Definition

Leqvio (inclisiran) is a medication that lowers LDL cholesterol levels by inhibiting the synthesis of PCSK9. It is administered as a subcutaneous injection and works in conjunction with statins.

5 Must Know Facts For Your Next Test

1. Leqvio is a small interfering RNA (siRNA) therapy that targets PCSK9 production in the liver.
2. It is typically administered every six months after an initial dosing schedule.
3. Leqvio can be used alongside statins to achieve further reduction in LDL cholesterol levels.
4. The drug has been shown to reduce LDL cholesterol by approximately 50% in clinical trials.
5. Common side effects include injection site reactions, respiratory tract infections, and muscle pain.

Review Questions

• How does Leqvio function to lower LDL cholesterol?
• What is the typical administration schedule for Leqvio?
• Name two common side effects of Leqvio.

Related terms

Statins: Medications that inhibit HMG-CoA reductase to lower cholesterol levels.

PCSK9 Inhibitors: A class of drugs that inhibit proprotein convertase subtilisin/kexin type 9 to reduce LDL cholesterol.

LDL Cholesterol: Low-density lipoprotein cholesterol, often referred to as 'bad' cholesterol because high levels can lead to plaque buildup in arteries.