Leptin

Definition

Leptin is a hormone produced by adipose tissue that regulates energy balance by inhibiting hunger, which in turn helps to modulate body weight. It acts on receptors in the hypothalamus to signal satiety and reduce food intake.

5 Must Know Facts For Your Next Test

1. Leptin is primarily produced by adipocytes (fat cells) and plays a crucial role in long-term regulation of body weight.
2. The leptin receptor, also known as LEPR or Ob-R, is located in the hypothalamus of the brain.
3. Leptin resistance, where the body doesn't respond effectively to leptin signals, is often seen in obesity.
4. Low leptin levels are associated with increased appetite and decreased energy expenditure.
5. Pharmacological interventions targeting leptin pathways are being explored as potential treatments for obesity.

Review Questions

• What role does leptin play in regulating body weight?
• Where are leptin receptors primarily located?
• How does leptin resistance contribute to obesity?

Related terms

Ghrelin:

A hormone that stimulates appetite, often referred to as the 'hunger hormone'.

Adipose Tissue: Body fat that stores energy and produces hormones like leptin.

Hypothalamus:

A region of the brain responsible for regulating hunger, thirst, and other homeostatic systems.