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Jynarque

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Pharmacology for Nurses

Definition

Jynarque is a brand name for tolvaptan, a vasopressin V2 receptor antagonist used to treat autosomal dominant polycystic kidney disease (ADPKD). It helps reduce kidney cyst growth and preserve kidney function.

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5 Must Know Facts For Your Next Test

  1. Jynarque works by inhibiting the action of vasopressin on the kidneys, reducing cyst formation and growth.
  2. It is specifically approved for use in patients with rapidly progressing ADPKD.
  3. Common side effects include increased thirst, frequent urination, and potential liver injury.
  4. Patients taking Jynarque require regular liver function tests due to the risk of serious liver damage.
  5. Jynarque is contraindicated in patients with significant liver impairment or those unable to perceive or respond to thirst.

Review Questions

  • What is the primary therapeutic use of Jynarque?
  • How does Jynarque act at the molecular level?
  • Why are regular liver function tests necessary for patients taking Jynarque?

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