Isosorbide dinitrate

Definition

Isosorbide dinitrate is a nitrate used to prevent and treat angina pectoris. It works by dilating blood vessels, reducing cardiac workload, and improving oxygen delivery to the heart.

5 Must Know Facts For Your Next Test

1. Isosorbide dinitrate is often prescribed for chronic management of angina rather than acute relief.
2. The drug can cause common side effects such as headaches, dizziness, and hypotension.
3. It is metabolized in the liver to its active form, isosorbide mononitrate.
4. Patients should avoid sudden discontinuation of the drug to prevent rebound angina.
5. Isosorbide dinitrate can interact with phosphodiesterase inhibitors like sildenafil, leading to severe hypotension.

Review Questions

• What is the primary therapeutic use of isosorbide dinitrate?
• Which organ metabolizes isosorbide dinitrate into its active form?
• Name a common side effect associated with isosorbide dinitrate.

Related terms

Nitroglycerin:

Another nitrate used for both acute relief and prevention of angina.

Isosorbide Mononitrate: An active metabolite of isosorbide dinitrate with similar antianginal effects.

Phosphodiesterase Inhibitors:

A class of drugs that can dangerously interact with nitrates causing severe hypotension.