Irreversible AChE inhibitors are compounds that permanently inactivate acetylcholinesterase, leading to prolonged cholinergic effects. They are often used in the treatment of certain medical conditions and can also be toxic.
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Irreversible AChE inhibitors bind covalently to the enzyme acetylcholinesterase.
They cause a persistent increase in acetylcholine levels at synapses.
These inhibitors are used in the treatment of glaucoma and have applications as insecticides and nerve agents.
Exposure to these inhibitors can lead to symptoms such as muscle twitching, respiratory distress, and convulsions due to excessive cholinergic stimulation.
Pralidoxime (2-PAM) is an antidote that can reactivate acetylcholinesterase if administered before aging occurs.
Review Questions
What is the primary mechanism by which irreversible AChE inhibitors affect neurotransmission?
Name one medical use for irreversible AChE inhibitors and explain how it works.
What are some potential symptoms of poisoning with an irreversible AChE inhibitor?
Related terms
Acetylcholinesterase (AChE): An enzyme that breaks down acetylcholine into acetic acid and choline.
Myasthenia Gravis: An autoimmune disorder characterized by weakness and rapid fatigue of voluntary muscles due to impaired neuromuscular transmission.
Pralidoxime (2-PAM): A drug used to reactivate acetylcholinesterase that has been inhibited by organophosphates, provided it is given before aging occurs.