Indocin

Definition

Indocin is a brand name for indomethacin, a nonsteroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain. It works by inhibiting the production of prostaglandins, which are chemicals responsible for inflammation and pain.

5 Must Know Facts For Your Next Test

1. Indocin is commonly prescribed for conditions such as arthritis, gout, and bursitis.
2. It inhibits the enzyme cyclooxygenase (COX), which is crucial in the synthesis of prostaglandins.
3. Indocin can cause gastrointestinal side effects such as ulcers and bleeding.
4. Patients with known heart disease or risk factors for cardiovascular disease should use Indocin cautiously due to an increased risk of cardiovascular events.
5. It should not be used in patients with severe renal impairment without close monitoring.

Review Questions

• What enzyme does Indocin inhibit to exert its anti-inflammatory effects?
• List two common conditions for which Indocin is prescribed.
• What are two potential side effects associated with long-term use of Indocin?

Related terms

Prostaglandins: Lipid compounds that have diverse hormone-like effects, including promoting inflammation.

Cyclooxygenase (COX): An enzyme responsible for the formation of important biological mediators like prostaglandins.

Nonsteroidal Anti-inflammatory Drugs (NSAIDs): A class of drugs that provide analgesic and anti-inflammatory effects by inhibiting COX enzymes.