Indirect-acting cholinergic agonists
from class: Pharmacology for Nurses Definition Indirect-acting cholinergic agonists are drugs that inhibit the enzyme acetylcholinesterase, leading to increased levels of acetylcholine in synapses. They are used to treat conditions like Myasthenia Gravis and Alzheimer's Disease by enhancing cholinergic transmission.
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Predict what's on your test 5 Must Know Facts For Your Next Test Indirect-acting cholinergic agonists work by inhibiting acetylcholinesterase, preventing the breakdown of acetylcholine. These drugs improve muscle strength in Myasthenia Gravis patients by increasing neuromuscular transmission. In Alzheimer's Disease, they may help improve cognitive function by enhancing cholinergic activity in the brain. Common side effects include nausea, diarrhea, and increased salivation due to heightened parasympathetic activity. Examples of indirect-acting cholinergic agonists include donepezil, rivastigmine, and pyridostigmine. Review Questions How do indirect-acting cholinergic agonists increase acetylcholine levels? What are common side effects associated with these drugs? Name two conditions treated with indirect-acting cholinergic agonists.
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