Hepatotoxicity

Definition

Hepatotoxicity is the occurrence of liver damage due to exposure to certain substances, including drugs. It can lead to serious health complications and requires careful monitoring.

5 Must Know Facts For Your Next Test

1. Acetaminophen overdose is a leading cause of hepatotoxicity.
2. Elevated liver enzymes in blood tests are indicators of hepatotoxicity.
3. Nonopioid analgesics like NSAIDs can also contribute to hepatotoxicity, especially with prolonged use.
4. Symptoms of hepatotoxicity include jaundice, fatigue, and abdominal pain.
5. Management often involves discontinuation of the offending drug and supportive care.

Review Questions

• What are the common symptoms of hepatotoxicity?
• Which nonopioid analgesic is most commonly associated with causing hepatotoxicity?
• How is hepatotoxicity typically detected in patients?

Related terms

Nonopioid Analgesics:

Drugs that relieve pain without acting on opioid receptors.

Liver Enzymes:

Proteins that speed up chemical reactions in the liver; elevated levels can indicate liver damage.

NSAIDs:

Nonsteroidal anti-inflammatory drugs used for pain relief that can cause gastrointestinal and liver issues with long-term use.