Granisetron
from class: Pharmacology for Nurses Definition Granisetron is a 5-HT3 receptor antagonist used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. It works by blocking the action of serotonin in the brain and gut.
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Predict what's on your test 5 Must Know Facts For Your Next Test Granisetron is most commonly administered via oral tablets, transdermal patches, or intravenous injections. It specifically targets and blocks serotonin receptors in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract. Side effects may include headache, constipation, and dizziness; however, it generally has a favorable safety profile. Granisetron is often preferred over other antiemetics for its longer duration of action and fewer side effects. It can be used off-label for treating nausea related to other conditions such as gastroparesis. Review Questions What type of receptor does Granisetron target to exert its antiemetic effects? List two common routes of administration for Granisetron. Name one potential side effect of Granisetron.
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