Glucagon-Like Peptide-1

Definition

Glucagon-Like Peptide-1 (GLP-1) is an incretin hormone that enhances insulin secretion in response to meals. It also slows gastric emptying and promotes satiety.

5 Must Know Facts For Your Next Test

1. GLP-1 agonists are used in the treatment of type 2 diabetes to improve glycemic control.
2. GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4).
3. Common side effects of GLP-1 receptor agonists include nausea and vomiting.
4. GLP-1 receptor agonists can lead to weight loss, making them useful in weight management for diabetic patients.
5. Examples of GLP-1 receptor agonists include exenatide and liraglutide.

Review Questions

• What role does GLP-1 play in insulin secretion?
• Why are GLP-1 receptor agonists beneficial for weight management?
• Name two common examples of GLP-1 receptor agonists.

Related terms

Insulin: A hormone produced by the pancreas that regulates blood glucose levels.

Dipeptidyl Peptidase-4 (DPP-4): An enzyme that degrades incretin hormones like GLP-1.

Exenatide: A GLP-1 receptor agonist used to treat type 2 diabetes.