Ghrelin

Definition

Ghrelin is a hormone produced primarily in the stomach that stimulates appetite and promotes fat storage. It is often referred to as the 'hunger hormone' due to its role in regulating food intake.

5 Must Know Facts For Your Next Test

1. Ghrelin levels increase before meals and decrease after eating.
2. It activates growth hormone secretagogue receptor (GHS-R) which influences appetite.
3. High ghrelin levels are associated with increased hunger and weight gain.
4. Ghrelin has a role in energy balance by promoting fat storage and decreasing energy expenditure.
5. Pharmacological interventions targeting ghrelin are being researched for weight management therapies.

Review Questions

• What is the primary function of ghrelin?
• How do ghrelin levels fluctuate in relation to meals?
• What receptor does ghrelin activate, and what is its significance?

Related terms

Leptin:

A hormone produced by adipose cells that helps regulate energy balance by inhibiting hunger.

Growth Hormone Secretagogue Receptor (GHS-R): A receptor activated by ghrelin that plays a significant role in stimulating appetite.

Corticotropin-Releasing Hormone (CRH): A hormone involved in stress response that can suppress appetite.