Folate Antimetabolites
from class: Pharmacology for Nurses Definition Folate antimetabolites are a class of chemotherapeutic drugs that inhibit the use of folate, essential for DNA synthesis and cell division. By disrupting folate metabolism, these drugs hinder cancer cell growth.
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Predict what's on your test 5 Must Know Facts For Your Next Test Folate antimetabolites work by inhibiting the enzyme dihydrofolate reductase (DHFR). Methotrexate is one of the most commonly used folate antimetabolites in cancer therapy. These drugs are used to treat various types of cancers including leukemia, lymphoma, and breast cancer. Side effects can include bone marrow suppression, gastrointestinal toxicity, and mucositis. Leucovorin is often administered alongside methotrexate to reduce its toxic effects on normal cells. Review Questions What is the primary mechanism of action for folate antimetabolites? Name a commonly used folate antimetabolite in cancer therapy. Why might leucovorin be administered with methotrexate?
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