Fibrosis

Definition

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue, often as a reparative response to injury or damage. It can lead to the hardening and scarring of tissues, impairing their normal function.

5 Must Know Facts For Your Next Test

1. Fibrosis can occur as a side effect of certain chemotherapeutic drugs, particularly alkylating agents and antimetabolites.
2. Chronic inflammation from cancer treatments can trigger fibroblast activation, leading to fibrosis.
3. Pulmonary fibrosis is a specific type that affects the lungs, often seen in patients undergoing radiation therapy for lung cancer.
4. Hepatic fibrosis involves liver tissue and may result from chemotherapy-induced liver damage and chronic use of hepatotoxic drugs.
5. Management of fibrosis may include the use of antifibrotic agents, corticosteroids, and lifestyle modifications to limit further tissue damage.

Review Questions

• What are some common chemotherapeutic drugs that can lead to fibrosis?
• How does chronic inflammation contribute to the development of fibrosis?
• What are potential treatment options for managing fibrosis in cancer patients?

Related terms

chemotherapy: A type of cancer treatment that uses one or more anti-cancer drugs as part of a standardized regimen.

fibroblast: A type of cell that synthesizes the extracellular matrix and collagen, playing a critical role in wound healing and fibrosis.

antifibrotic agents: Medications used to prevent or reduce the formation of fibrous tissue.