Fenofibrate
from class: Pharmacology for Nurses Definition Fenofibrate is a lipid-lowering medication that primarily targets triglycerides and increases high-density lipoprotein (HDL) levels. It is used to treat hyperlipidemia and hypertriglyceridemia.
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Predict what's on your test 5 Must Know Facts For Your Next Test Fenofibrate activates peroxisome proliferator-activated receptor-alpha (PPAR-α) to enhance lipid metabolism. It significantly reduces serum triglycerides and can moderately increase HDL cholesterol levels. Common side effects include gastrointestinal discomfort, muscle pain, and an increased risk of gallstones. It can be used as an adjunctive therapy with statins for patients who need further lipid control. Fenofibrate is contraindicated in patients with severe liver or kidney dysfunction. Review Questions What is the primary mechanism of action for Fenofibrate? Which lipid profiles are most affected by Fenofibrate treatment? What are common side effects associated with Fenofibrate use?
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