Ezetimibe

Definition

Ezetimibe is a medication used to lower cholesterol levels by inhibiting the absorption of cholesterol in the small intestine. It is often prescribed alongside statins for an additive effect on lowering LDL cholesterol.

5 Must Know Facts For Your Next Test

1. Ezetimibe selectively inhibits the Niemann-Pick C1-Like 1 (NPC1L1) protein involved in cholesterol absorption.
2. It can reduce LDL cholesterol by approximately 18-25% when used alone.
3. Common side effects include gastrointestinal discomfort and upper respiratory tract infections.
4. Ezetimibe does not significantly affect the absorption of triglycerides or fat-soluble vitamins.
5. It is often combined with statins to enhance lipid-lowering effects and has been shown to significantly reduce cardiovascular events in combination therapy.

Review Questions

• What protein does Ezetimibe inhibit to reduce cholesterol absorption?
• What are common side effects associated with Ezetimibe?
• Why might Ezetimibe be prescribed alongside statins?

Related terms

Statins: A class of drugs that reduce cholesterol levels by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol production.

LDL Cholesterol: Low-density lipoprotein cholesterol, often referred to as 'bad' cholesterol, which can accumulate in arteries leading to cardiovascular diseases.

NPC1L1 Protein: Niemann-Pick C1-Like 1 protein responsible for the uptake of cholesterol from the small intestine into enterocytes.