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Extracellular fluid

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Pharmacology for Nurses

Definition

Extracellular fluid (ECF) is the body fluid located outside cells, comprising interstitial fluid and plasma. It plays a critical role in maintaining homeostasis by facilitating nutrient, gas, and waste exchange.

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5 Must Know Facts For Your Next Test

  1. ECF accounts for about one-third of the total body water.
  2. It includes important components such as electrolytes (sodium, chloride, and bicarbonate).
  3. The balance of ECF is vital for proper cellular function and overall homeostasis.
  4. Alterations in ECF volume can lead to conditions like edema or dehydration.
  5. Pharmacological agents often affect ECF composition, impacting drug distribution and efficacy.

Review Questions

  • What are the main components of extracellular fluid?
  • How does extracellular fluid contribute to homeostasis?
  • What might be the consequences of an imbalance in extracellular fluid volume?
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