Erlotinib

Definition

Erlotinib is a tyrosine kinase inhibitor used to treat non-small cell lung cancer and pancreatic cancer. It works by inhibiting the epidermal growth factor receptor (EGFR).

5 Must Know Facts For Your Next Test

1. Erlotinib targets and inhibits the epidermal growth factor receptor (EGFR) on cancer cells.
2. It is primarily used in the treatment of non-small cell lung cancer and pancreatic cancer.
3. Common side effects include rash, diarrhea, and fatigue.
4. Erlotinib is administered orally in tablet form.
5. Patients with EGFR mutations are more likely to respond positively to Erlotinib therapy.

Review Questions

• What types of cancer is Erlotinib primarily used to treat?
• How does Erlotinib work at the cellular level?
• What are common side effects associated with Erlotinib?

Related terms

Tyrosine Kinase Inhibitor: A class of drugs that blocks the action of enzymes involved in the activation of various proteins by signal transduction.

Epidermal Growth Factor Receptor (EGFR): A protein on the surface of cells that binds to epidermal growth factor, leading to cell proliferation.

Non-Small Cell Lung Cancer (NSCLC): The most common type of lung cancer, which includes adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.