Eplerenone

Definition

Eplerenone is a selective aldosterone receptor antagonist used to treat heart failure and hypertension. It works by blocking the effects of aldosterone, which reduces sodium reabsorption and increases potassium retention.

5 Must Know Facts For Your Next Test

1. Eplerenone is a potassium-sparing diuretic that helps reduce fluid overload in heart failure patients.
2. It specifically blocks aldosterone receptors in the distal nephron of the kidney.
3. Common side effects include hyperkalemia, dizziness, and renal function impairment.
4. Eplerenone is often used when patients cannot tolerate spironolactone due to its more selective action causing fewer endocrine side effects.
5. It is metabolized primarily by the CYP3A4 enzyme, so drug interactions with CYP3A4 inhibitors or inducers should be monitored.

Review Questions

• What class of drug is Eplerenone, and what condition is it commonly used to treat?
• How does Eplerenone differ from other potassium-sparing diuretics like spironolactone?
• What are some common side effects associated with Eplerenone?

Related terms

Spironolactone:

A non-selective aldosterone antagonist also used to treat heart failure but with more endocrine-related side effects.

Hyperkalemia:

An elevated level of potassium in the blood, a common side effect of potassium-sparing diuretics.

CYP3A4 Inhibitors:

Drugs that can inhibit the CYP3A4 enzyme, potentially affecting the metabolism of eplerenone.