Entresto is a combination drug containing sacubitril and valsartan, used to treat heart failure. It works by inhibiting neprilysin and blocking angiotensin II receptors.
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Entresto reduces the risk of cardiovascular death and hospitalization due to heart failure.
Sacubitril in Entresto inhibits neprilysin, leading to increased levels of natriuretic peptides.
Valsartan in Entresto blocks angiotensin II receptors, reducing vasoconstriction and aldosterone secretion.
It is typically prescribed for patients with chronic heart failure with reduced ejection fraction (HFrEF).
Patients taking Entresto should be monitored for potential side effects such as hypotension, hyperkalemia, and renal impairment.
Review Questions
What are the two active components of Entresto?
How does sacubitril in Entresto help manage heart failure?
What are some common side effects associated with taking Entresto?
Related terms
Neprilysin Inhibitor: A class of drugs that prevent the breakdown of natriuretic peptides, enhancing their beneficial effects in heart failure.
Angiotensin II Receptor Blocker (ARB): Medications that block the action of angiotensin II, leading to vasodilation and decreased blood pressure.
Heart Failure with Reduced Ejection Fraction (HFrEF): A condition where the heart muscle does not contract effectively, resulting in inadequate blood flow to meet the body's needs.