Doxil

Definition

Doxil is a liposomal formulation of the chemotherapeutic drug doxorubicin. It is designed to enhance drug delivery to cancer cells while reducing toxicity to healthy tissues.

5 Must Know Facts For Your Next Test

1. Doxil is encapsulated in liposomes, which helps reduce cardiotoxicity compared to conventional doxorubicin.
2. It is commonly used to treat ovarian cancer, multiple myeloma, and Kaposi's sarcoma.
3. The liposomal structure allows for prolonged circulation time in the bloodstream.
4. Patients receiving Doxil may experience hand-foot syndrome as a side effect.
5. Doxil’s dosing differs from traditional doxorubicin due to its altered pharmacokinetics.

Review Questions

• What are the major advantages of using Doxil over conventional doxorubicin?
• List three types of cancers that are commonly treated with Doxil.
• Describe a common side effect associated with Doxil and explain its cause.

Related terms

Liposomal Drug Delivery: A method that uses lipid-based vesicles to deliver drugs more effectively and reduce toxicity.

Hand-Foot Syndrome: A side effect characterized by redness, swelling, and pain on the palms of the hands or soles of the feet.

Pharmacokinetics:

The study of how a drug is absorbed, distributed, metabolized, and excreted in the body.