Declomycin

Definition

Declomycin is an antibiotic in the tetracycline class that is used off-label to treat hyponatremia caused by the syndrome of inappropriate antidiuretic hormone secretion (SIADH). It works by inhibiting the action of antidiuretic hormone (ADH) on the kidneys.

5 Must Know Facts For Your Next Test

1. Declomycin inhibits the renal action of ADH, making it useful in treating SIADH.
2. It belongs to the tetracycline class of antibiotics and has antibacterial properties.
3. Common side effects include photosensitivity, gastrointestinal disturbances, and potential for nephrotoxicity.
4. Declomycin should be taken on an empty stomach to enhance absorption.
5. It can cause permanent discoloration of teeth if used during tooth development in children.

Review Questions

• What condition is Declomycin commonly used off-label to treat?
• What class of antibiotics does Declomycin belong to?
• Name two common side effects of Declomycin.

Related terms

Tetracyclines: A class of broad-spectrum antibiotics that includes drugs like doxycycline and minocycline.

SIADH: Syndrome of Inappropriate Antidiuretic Hormone Secretion, a condition where excessive ADH leads to water retention and hyponatremia.

Antidiuretic Hormone (ADH): A hormone that promotes water retention in the kidneys by increasing water reabsorption.