Dactinomycin
from class:
Pharmacology for Nurses
Definition
Dactinomycin is an antineoplastic antibiotic used in cancer therapy. It inhibits RNA synthesis, leading to cell death.
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5 Must Know Facts For Your Next Test
- Dactinomycin is particularly effective against Wilms' tumor and rhabdomyosarcoma.
- It works by binding to DNA and preventing RNA polymerase from transcribing mRNA.
- Common side effects include nausea, vomiting, and bone marrow suppression.
- Dactinomycin is administered intravenously due to poor oral absorption.
- It is often used in combination with other chemotherapeutic agents to enhance efficacy.
Review Questions
- What type of cancers is Dactinomycin commonly used to treat?
- How does Dactinomycin inhibit cancer cell growth?
- What are some common side effects associated with Dactinomycin?
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