Cymbalta

Definition

Cymbalta, also known as duloxetine, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder and generalized anxiety disorder. It also has applications in managing neuropathic pain.

5 Must Know Facts For Your Next Test

1. Cymbalta works by increasing the levels of serotonin and norepinephrine in the brain.
2. Common side effects include nausea, dry mouth, and fatigue.
3. It is contraindicated in patients with uncontrolled narrow-angle glaucoma.
4. Cymbalta is metabolized primarily by the liver enzyme CYP1A2.
5. Abrupt discontinuation can lead to withdrawal symptoms such as dizziness and irritability.

Review Questions

• What are the primary neurotransmitters affected by Cymbalta?
• List two common side effects of Cymbalta.
• Why is Cymbalta contraindicated in patients with uncontrolled narrow-angle glaucoma?

Related terms

Serotonin-Norepinephrine Reuptake Inhibitor (SNRI): A class of drugs that increase levels of serotonin and norepinephrine in the brain.

Major Depressive Disorder: A mood disorder characterized by persistent feelings of sadness and loss of interest.

Neuropathic Pain: Pain caused by damage or disease affecting the somatosensory nervous system.