Cyclosporine

Definition

Cyclosporine is an immunosuppressive agent used to reduce inflammation in ocular conditions. It is commonly administered as eye drops for treating chronic dry eye disease and other inflammatory eye disorders.

5 Must Know Facts For Your Next Test

1. Cyclosporine works by inhibiting T-cell activation, which reduces immune-mediated inflammation in the eyes.
2. It is primarily used to treat moderate to severe dry eye syndrome that has not improved with artificial tears alone.
3. The typical concentration for ophthalmic cyclosporine solutions is 0.05%.
4. Common side effects include a burning sensation upon administration and temporary blurred vision.
5. Patients are usually advised to use cyclosporine eye drops twice daily, approximately 12 hours apart.

Review Questions

• How does cyclosporine help in treating chronic dry eye syndrome?
• What is the usual concentration of cyclosporine in ophthalmic solutions?
• Name two common side effects associated with the use of cyclosporine eye drops.

Related terms

Artificial Tears:

Lubricating eye drops used to relieve dryness and irritation.

T-cell Activation:

A process by which T-cells are primed to respond to antigens, playing a crucial role in the immune response.

Ocular Surface Disease: A group of disorders affecting the surface of the cornea and conjunctiva, often leading to discomfort and visual disturbances.