COMT inhibitors (Catechol-O-methyltransferase inhibitors) are medications that block the enzyme COMT, which breaks down dopamine. They are used to prolong the effect of levodopa in treating Parkinson’s disease.
5 Must Know Facts For Your Next Test
COMT inhibitors help increase and sustain the levels of dopamine in the brain.
They are often used in combination with levodopa/carbidopa therapy.
Commonly prescribed COMT inhibitors include entacapone and tolcapone.
Tolcapone is associated with a risk of liver toxicity and requires regular monitoring.
Side effects can include diarrhea, urine discoloration, and orthostatic hypotension.
Review Questions
What is the primary function of COMT inhibitors in Parkinson's disease treatment?
Name two commonly prescribed COMT inhibitors.
Why does tolcapone require regular liver function monitoring?
Related terms
Levodopa: A precursor to dopamine used as a primary treatment for Parkinson's disease.
Carbidopa: A drug that prevents the conversion of levodopa into dopamine outside the brain.
Dopamine Agonists: Medications that mimic dopamine effects by directly stimulating its receptors.