Cholestyramine

Definition

Cholestyramine is a bile acid sequestrant that binds bile acids in the intestine to prevent their reabsorption. It is used primarily to lower cholesterol levels and treat pruritus associated with partial biliary obstruction.

5 Must Know Facts For Your Next Test

1. Cholestyramine works by forming an insoluble complex with bile acids, which are then excreted in the feces.
2. It can cause gastrointestinal side effects such as constipation, bloating, and abdominal discomfort.
3. Cholestyramine may interfere with the absorption of fat-soluble vitamins (A, D, E, K) and other medications.
4. Patients should take other medications at least 1 hour before or 4-6 hours after cholestyramine to avoid drug interactions.
5. It is often prescribed as part of a treatment plan that includes diet changes and exercise.

Review Questions

• How does cholestyramine help lower cholesterol levels?
• What are common side effects associated with cholestyramine?
• Why should patients space out the timing of cholestyramine and other medications?

Related terms

Bile Acid Sequestrants: A class of drugs that bind bile acids in the intestine to prevent their reabsorption.

Fibrates: A class of lipid-lowering drugs primarily used to reduce triglyceride levels.

Niacin: A form of vitamin B3 used to lower cholesterol levels and improve cardiovascular health.