Cannabinoids

Definition

Cannabinoids are chemical compounds found in cannabis that interact with the body's endocannabinoid system to produce various physiological effects. They can be used therapeutically, including as antiemetics to reduce nausea and vomiting.

5 Must Know Facts For Your Next Test

1. Cannabinoids like dronabinol are FDA-approved for managing chemotherapy-induced nausea and vomiting.
2. The primary psychoactive cannabinoid is tetrahydrocannabinol (THC), which also has antiemetic properties.
3. Cannabinoids exert their effects by binding to CB1 receptors in the central nervous system.
4. They may cause side effects such as dizziness, euphoria, and altered mental status.
5. Cannabinoids can be administered orally or through inhalation for antiemetic purposes.

Review Questions

• What is the main mechanism by which cannabinoids reduce nausea and vomiting?
• Name an FDA-approved cannabinoid used for chemotherapy-induced nausea.
• List two common side effects of cannabinoids when used as antiemetics.

Related terms

Endocannabinoid System: A complex cell-signaling system involved in regulating a variety of physiological processes.

Dronabinol:

A synthetic form of THC used to treat nausea and vomiting caused by chemotherapy.

CB1 Receptors: Receptors located primarily in the central nervous system that mediate the effects of cannabinoids.