Bile acid sequestrants

Definition

Bile acid sequestrants are a class of drugs that bind bile acids in the intestine, preventing their reabsorption. This leads to increased conversion of cholesterol into bile acids, thereby lowering blood cholesterol levels.

5 Must Know Facts For Your Next Test

1. Bile acid sequestrants are primarily used to lower LDL cholesterol levels.
2. They work by interrupting the enterohepatic circulation of bile acids.
3. Common side effects include gastrointestinal issues such as constipation and bloating.
4. Cholestyramine, colestipol, and colesevelam are examples of bile acid sequestrants.
5. These drugs can interfere with the absorption of fat-soluble vitamins (A, D, E, K) and other medications.

Review Questions

• How do bile acid sequestrants help in lowering LDL cholesterol levels?
• Name three common side effects associated with bile acid sequestrants.
• List two examples of bile acid sequestrants.

Related terms

Lipoproteins:

Molecules made of proteins and fat that transport lipids in the blood.

Apolipoproteins: Proteins that bind lipids to form lipoproteins.

Fibrates:

A class of drugs primarily used to reduce triglyceride levels and increase HDL cholesterol.