Autoantibodies

Definition

Autoantibodies are antibodies produced by the immune system that mistakenly target and react with a person's own tissues or organs. They play a crucial role in autoimmune diseases such as myasthenia gravis.

5 Must Know Facts For Your Next Test

1. Autoantibodies in myasthenia gravis primarily target acetylcholine receptors at the neuromuscular junction.
2. The presence of autoantibodies leads to muscle weakness and fatigue, hallmark symptoms of myasthenia gravis.
3. Diagnostic tests for myasthenia gravis often include assays to detect specific autoantibodies like anti-AChR antibodies.
4. Treatment strategies for conditions involving autoantibodies may include immunosuppressants to reduce antibody production.
5. Autoantibodies can also be involved in other neurological disorders, highlighting their broad impact on health.

Review Questions

• What are autoantibodies and how do they affect the body?
• Which specific receptor is targeted by autoantibodies in myasthenia gravis?
• Name one diagnostic method used to detect autoantibodies in patients suspected of having myasthenia gravis.

Related terms

Myasthenia Gravis: An autoimmune disorder characterized by weakness and rapid fatigue of voluntary muscles due to impaired communication between nerves and muscles.

Acetylcholine Receptor (AChR): A protein that responds to the neurotransmitter acetylcholine, important for muscle contraction.

Immunosuppressants: Medications that inhibit or prevent activity of the immune system, used to treat autoimmune diseases.