Alpha-synuclein

Definition

Alpha-synuclein is a protein found primarily in neural tissue, implicated in the pathogenesis of Parkinson's disease. It aggregates to form Lewy bodies, which are a hallmark of the disease.

5 Must Know Facts For Your Next Test

1. Alpha-synuclein is encoded by the SNCA gene.
2. Misfolded alpha-synuclein proteins aggregate to form Lewy bodies.
3. Lewy bodies disrupt neuronal function leading to cell death.
4. Mutations and duplications in the SNCA gene can increase Parkinson's disease risk.
5. Alpha-synuclein is a target for therapeutic interventions aimed at preventing or reducing its aggregation.

Review Questions

• What role does alpha-synuclein play in Parkinson's disease?
• How do mutations in the SNCA gene affect alpha-synuclein?
• What are Lewy bodies and how are they related to alpha-synuclein?

Related terms

Lewy Bodies: Protein aggregates found in neurons, associated with Parkinson's disease.

SNCA Gene: The gene that encodes the alpha-synuclein protein.

Neurodegeneration: The progressive loss of structure or function of neurons, including their death.