Adenosine
Definition
Adenosine is an endogenous nucleoside that acts on the heart to slow conduction through the AV node, often used in emergency settings to treat supraventricular tachycardia. It has a very short half-life, typically less than 10 seconds.
5 Must Know Facts For Your Next Test
- Adenosine is primarily used for acute conversion of paroxysmal supraventricular tachycardia (PSVT) to a normal sinus rhythm.
- The drug has a very short half-life, necessitating rapid intravenous administration followed by a saline flush.
- Common side effects include facial flushing, chest pain, and shortness of breath due to its rapid action on the cardiovascular system.
- Adenosine works by activating adenosine receptors, which leads to hyperpolarization and transient heart block in the AV node.
- It is contraindicated in patients with second- or third-degree AV block without a pacemaker.
Review Questions
- What is the primary use of Adenosine in emergency cardiac care?
- Why is rapid intravenous administration followed by a saline flush necessary when administering Adenosine?
- List at least two common side effects associated with Adenosine.
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Related terms
Supraventricular Tachycardia (SVT): A type of fast heart rate originating above the ventricles.
AV Node: Part of the electrical conduction system of the heart that coordinates the top of the heart.
Half-Life: The time required for the concentration of a drug to reduce to half its initial value.
