AChE inhibitors
Definition
AChE inhibitors are drugs that block the action of acetylcholinesterase, an enzyme responsible for breaking down acetylcholine in the synaptic cleft. This increase in acetylcholine levels can enhance cholinergic transmission and improve symptoms in conditions like Myasthenia Gravis and Alzheimer's Disease.
5 Must Know Facts For Your Next Test
- AChE inhibitors help to increase levels of acetylcholine, which is crucial for muscle function and cognitive processes.
- Common AChE inhibitors used in treating Alzheimer's Disease include donepezil, rivastigmine, and galantamine.
- For Myasthenia Gravis, pyridostigmine is a frequently prescribed AChE inhibitor.
- Side effects of AChE inhibitors can include nausea, diarrhea, muscle cramps, and bradycardia due to increased cholinergic activity.
- AChE inhibitors are not a cure but can provide symptomatic relief and improve quality of life.
Review Questions
- What is the primary mechanism by which AChE inhibitors work?
- Name two AChE inhibitors commonly used in the treatment of Alzheimer's Disease.
- What are some common side effects associated with AChE inhibitors?
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Related terms
Acetylcholinesterase: An enzyme that breaks down acetylcholine in the synaptic cleft.
Donepezil: An AChE inhibitor used primarily for managing symptoms of Alzheimer's Disease.
Pyridostigmine: An AChE inhibitor commonly used to treat Myasthenia Gravis.
