Acetylcholinesterase inhibitor
Definition
Acetylcholinesterase inhibitors are drugs that prevent the breakdown of acetylcholine, a neurotransmitter, by inhibiting the enzyme acetylcholinesterase. This results in increased acetylcholine levels in the synapses, enhancing cholinergic transmission.
5 Must Know Facts For Your Next Test
- Acetylcholinesterase inhibitors are often used to treat conditions like Alzheimer's disease and myasthenia gravis.
- These inhibitors can cause side effects such as bradycardia, muscle cramps, and increased salivation.
- Common examples include donepezil, rivastigmine, and galantamine.
- They may interact with other medications that affect cholinergic systems, such as anticholinergics.
- Acetylcholinesterase inhibitors can cross the blood-brain barrier and influence central nervous system activities.
Review Questions
- What is the primary function of an acetylcholinesterase inhibitor?
- Name two medical conditions that are commonly treated with acetylcholinesterase inhibitors.
- List three possible side effects of using acetylcholinesterase inhibitors.
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Related terms
Cholinergic Transmission: The process by which nerve cells communicate using the neurotransmitter acetylcholine.
Donepezil: A reversible acetylcholinesterase inhibitor used primarily to treat Alzheimer's disease.
Anticholinergics: Drugs that block the action of acetylcholine in the central and peripheral nervous system.
