5-alpha-reductase inhibitors
Definition
5-alpha-reductase inhibitors are medications that block the action of the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). They are commonly used to treat conditions like benign prostatic hyperplasia (BPH) and male pattern baldness.
5 Must Know Facts For Your Next Test
- 5-alpha-reductase inhibitors include drugs such as finasteride and dutasteride.
- These inhibitors reduce DHT levels, leading to decreased prostate size and improved urinary flow in BPH patients.
- Common side effects can include sexual dysfunction, such as decreased libido and erectile dysfunction.
- They may take several months to show noticeable effects on symptoms.
- These medications are contraindicated in women who are or may become pregnant due to potential birth defects.
Review Questions
- Name two common drugs that belong to the class of 5-alpha-reductase inhibitors.
- What is the primary mechanism of action for 5-alpha-reductase inhibitors?
- List two potential side effects associated with the use of 5-alpha-reductase inhibitors.
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Related terms
Benign Prostatic Hyperplasia (BPH): A condition characterized by an enlarged prostate gland causing urinary problems.
Dihydrotestosterone (DHT): An androgen hormone formed from testosterone that plays a role in the development of male characteristics and conditions like BPH.
Alpha Blockers: Medications that relax muscle tissue in blood vessels and the prostate, improving urine flow in BPH patients.
