Messenger RNA (mRNA)

Definition

Messenger RNA (mRNA) is a single-stranded molecule that carries the genetic instructions from the nucleus to the ribosomes, where protein synthesis takes place. It serves as a template for the production of specific proteins in the cell.

5 Must Know Facts For Your Next Test

1. mRNA is synthesized in the nucleus during the process of transcription, where the DNA template is copied into a complementary mRNA molecule.
2. The mRNA molecule is then transported out of the nucleus and into the cytoplasm, where it binds to ribosomes to direct the synthesis of a specific protein.
3. The sequence of nucleotides in the mRNA determines the sequence of amino acids in the resulting protein, as the ribosome reads the mRNA codon by codon and assembles the corresponding amino acids.
4. mRNA has a limited lifespan and is eventually degraded, allowing the cell to regulate the production of specific proteins in response to changing cellular needs.
5. Mutations or alterations in the mRNA sequence can lead to the production of abnormal or dysfunctional proteins, which can contribute to various genetic disorders and diseases.

Review Questions

• Explain the role of mRNA in the process of protein synthesis.
  • mRNA plays a crucial role in the process of protein synthesis, also known as translation. After the genetic information is transcribed from DNA into mRNA in the nucleus, the mRNA molecule is transported to the ribosomes in the cytoplasm. The ribosome then reads the mRNA sequence and uses it as a template to direct the synthesis of a specific protein by assembling the corresponding amino acids in the correct order. This process allows the cell to produce the necessary proteins for its various functions based on the genetic instructions encoded in the DNA.
• Describe the relationship between mRNA and the ribosome during protein synthesis.
  • The ribosome and mRNA work closely together during the process of protein synthesis. The ribosome is the cellular organelle responsible for the synthesis of proteins, and it uses the mRNA molecule as a template to direct the assembly of amino acids into a polypeptide chain. The mRNA molecule binds to the ribosome and provides the genetic instructions for the specific protein to be produced. The ribosome then reads the mRNA sequence codon by codon, and uses this information to select the appropriate transfer RNA (tRNA) molecules, which carry the corresponding amino acids. The ribosome then assembles these amino acids into a growing polypeptide chain, ultimately producing the desired protein.
• Analyze the importance of the limited lifespan of mRNA in the regulation of protein production within the cell.
  • The limited lifespan of mRNA molecules is crucial for the regulation of protein production within the cell. Because mRNA is eventually degraded, the cell can quickly adjust the production of specific proteins in response to changing cellular needs. This allows the cell to rapidly respond to environmental or developmental cues by increasing or decreasing the synthesis of particular proteins as required. The degradation of mRNA also prevents the continued production of proteins that are no longer needed, ensuring the efficient allocation of cellular resources. This dynamic regulation of protein synthesis through the controlled lifespan of mRNA is essential for maintaining the proper balance and function of the cell's proteome, which is the complete set of proteins expressed by the cell.

Related terms

Transcription:

The process by which the genetic information in DNA is copied into mRNA, which then carries this information to the ribosome for translation.

Translation:

The process by which the information encoded in mRNA is used to direct the synthesis of a specific protein by the ribosome.

Ribosome:

The cellular organelle responsible for the synthesis of proteins, where mRNA serves as a template for the assembly of amino acids into a polypeptide chain.