Pellagra

Definition

Pellagra is a nutritional deficiency disease caused by a lack of niacin (vitamin B3) or tryptophan. It manifests through symptoms known as the three Ds: dermatitis, diarrhea, and dementia.

5 Must Know Facts For Your Next Test

1. Pellagra primarily affects the skin, digestive system, and nervous system.
2. A diet deficient in niacin or its precursor tryptophan commonly leads to pellagra.
3. Symptoms can progress to neurological issues such as confusion, memory loss, and psychosis if untreated.
4. Pellagra was historically common in populations with corn-based diets low in niacin.
5. Treatment includes niacin supplementation and addressing dietary imbalances.

Review Questions

• What are the primary systems affected by pellagra?
• Which nutrient deficiencies lead to the development of pellagra?
• How is pellagra treated both nutritionally and medically?

Related terms

Niacin:

Also known as vitamin B3, it is essential for energy production and cellular metabolism.

Dermatitis:

Inflammation of the skin that can be a symptom of various conditions including pellagra.

Neuropathy: Damage or dysfunction of one or more nerves that can result from nutritional deficiencies like those seen in pellagra.